he Anti-Tau [pS199] antibody (Ref. 4BDX-1502) recognizes the phosphorylated serine 199 of Tau proteins. This antibody is suitable for Western Blot, for Immunohistochemistry and Immunofluorescence. This polyserum was obtained by immunizing a rabbit with a 12 amino acid peptide containing the phosphorylated serine 199 (SGYSSPGSPGT). This product is determined by its ability to recognise human Tau phosphorylated at serine 199.Tau proteins are encoded by a single gene MAPT (Gene ID: 4137). They belong to the family of microtubule-associated proteins. Neurofibrillary degeneration is characterized by an accumulation of fibrils made of hyper and abnormally phosphorylated Tau proteins. The Tau phosphorylation at serine 199 is an indicator of the early step of neurofibrillary degeneration. On human brain tissue or in animal models of tauopathies, this antibody detects specifically neurons in neurofibrillary degeneration. The serine 199 is phosphorylated by the following kinases: CDK5 (cyclin dependent kinase 5), CK2 (casein kinase 2), PKA (protein kinase A), GSK3 (glycogen synthase kinase 3), ERK/MAPK (mitogen activated kinases) and MARK (Microtubule-associated protein/microtubule affinity-regulating kinase).